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SUMMARY:Prof. Michal Hocek\, Charles University\, Prague (CZ): Base-modifi
 ed nucleotides and nucleic acids for chemical biology\, medicinal chemistr
 y and diagnostics
DTSTART;TZID=Europe/Berlin:20241105T090000
DTEND;TZID=Europe/Berlin:20241105T100000
DTSTAMP:20260613T215900Z
UID:e5b22c8eac874f879765498f20e79799@www2.hrz.uni-marburg.de
CREATED:20240212T111223Z
DESCRIPTION:https://www2.hrz.uni-marburg.de/en/synmikro/grk2937/whats-on/d
 ates-and-events/speaker-series-michal-hocek\nSpeaker Series. The Hocek gro
 up is interested in synthetic\, bioorganic and medicinal chemistry of nucl
 eic acids and their components. Novel types of modified derivatives and an
 alogues of nucleobases\, nucleosides\, nucleotides and nucleic acids are d
 esigned and prepared for applications in all areas of biomedicinal science
 s (medicinal chemistry\, biochemistry\, chemical biology\, bioanalysis etc
 .). Basic developments of methodology for the synthesis of these modified 
 biomolecules are performed largely using modern methods (including metal- 
 or enzyme-catalyzed reactions).\nBiological activity (antitumor\, antivira
 l etc.) of the novel nucleobases\, nucleosides and nucleotides is systemat
 ically studied in collaboration with several groups both in academia and i
 n pharmaceutical industry\, including mechanism of action and preclinical 
 development of promising new cytostatics.\nEnzymatic synthesis of function
 alized nucleic acids bearing diverse interesting and useful substituents i
 s developed and the modified oligonucleotides or nucleic acids are applied
  in bioanalysis (redox labelling for electrochemical detection or environm
 ent-sensitive fluorescence labelling for fluorescent microscopy) or in che
 mical biology (regulation of gene expression or cross-linking of DNA probe
 s with proteins).
LAST-MODIFIED:20240926T120134Z
LOCATION:SYNMIKRO Lecture Hall
URL:https://www2.hrz.uni-marburg.de/en/synmikro/grk2937/whats-on/dates-and
 -events/speaker-series-michal-hocek
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TZID:Europe/Berlin
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DTSTART:20241027T020000
TZNAME:CET
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
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