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SUMMARY:Dr. Maria Duca\, Université Côte d’Azur\, Nice (FR): Design of
  multifunctional conjugates for the targeting of non-coding RNAs: anticanc
 er and antimicrobial applications
DTSTART;TZID=Europe/Berlin:20241203T090000
DTEND;TZID=Europe/Berlin:20241203T100000
DTSTAMP:20260613T232012Z
UID:b1f291a5e73d4038a0de20cbed3000d8@www2.hrz.uni-marburg.de
CREATED:20240229T101517Z
DESCRIPTION:https://www2.hrz.uni-marburg.de/en/synmikro/grk2937/whats-on/d
 ates-and-events/speaker-series-maria-duca\nSpeaker Series. Abstract: RNA i
 s one of the most intriguing and promising biological targets for the disc
 overy of innovative drugs in a large number of pathologies and various bio
 logically relevant RNAs that could serve as drug targets have already been
  identified. Among the most important ones\, it is worth to mention prokar
 yotic ribosomal RNA which is the target of a number of currently employed 
 antibiotics\, viral RNAs such as TAR\, RRE and DIS RNA of HIV-1 or oncogen
 ic microRNAs that are tightly involved in the development and progression 
 of various cancers. However\, difficulties in the rational design of stron
 g and specific small-molecule ligands renders this kind of molecules relat
 ively rare. In this presentation\, we will show our recent results about t
 he structure-based design of new RNA ligands targeting oncogenic RNAs that
  led us to the identification of new compounds bearing a promising biologi
 cal activity but also to a better understanding of the formed interactions
  toward the design of optimized compounds. In parallel to the design of bi
 oactive compounds\, we also perform the screening of chemical library thus
  increasing the available chemical tools for the development of efficient 
 and specific RNA binders for a wide number of therapeutic applications. We
  will finally show the validation of a new antibacterial target and the de
 sign of original compounds bearing potential antimicrobial activity agains
 t resistant bacterial strains.
LAST-MODIFIED:20241120T120320Z
LOCATION:SYNMIKRO Lecture Hall
URL:https://www2.hrz.uni-marburg.de/en/synmikro/grk2937/whats-on/dates-and
 -events/speaker-series-maria-duca
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