BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Plone.org//NONSGML plone.app.event//EN
X-WR-TIMEZONE:Europe/Berlin
BEGIN:VEVENT
SUMMARY:Prof. Andrea Rentmeister\, Ludwig-Maximilians-Universität Münche
 n: Harnessing Click Chemistry and Light for Precise Analysis and Control o
 f mRNA
DTSTART;TZID=Europe/Berlin:20241217T090000
DTEND;TZID=Europe/Berlin:20241217T100000
DTSTAMP:20260614T064445Z
UID:5a2550083ad14c2f8ba1ce4ec236ddcb@www2.hrz.uni-marburg.de
CREATED:20240208T102514Z
DESCRIPTION:https://www2.hrz.uni-marburg.de/en/synmikro/grk2937/whats-on/d
 ates-and-events/speaker-series-andrea-rentmeister\nSpeaker Series. \nMesse
 nger RNAs (mRNAs) enable the production of almost any functional protein/p
 eptide in the human body as a vaccine or therapeutic agent. The translatio
 n of mRNA is a fundamental process in gene expression\, and controlling tr
 anslation is crucial for regulating the production of proteins in cells. I
 n addition\, internal modifications of mRNA have emerged as widespread and
  versatile regulatory mechanism to control gene expression at the post-tra
 nscriptional level. Most of these modifications are methyl groups\, making
  S-adenosyl-L-methionine (SAM) a central metabolic hub.\nWe established me
 tabolic labeling with a clickable metabolic precursor of SAM that enables 
 detection and identification of various methylation sites. Integration int
 o next generation sequencing enabled mapping of N6-methyladenosine (m6A) a
 nd 5-methylcytidine (m5C) sites in mRNA with single nucleotide precision a
 nd independent of antibodies.\nIn a different project\, we aimed to contro
 l translation of mRNA by light as external stimulus. We synthesized 5′ c
 ap analogues with photo-cleavable groups (FlashCaps) that prohibit binding
  to the eukaryotic translation initiation factor eIF4E. These compounds ar
 e compatible with the general and efficient production of mRNAs by in vitr
 o transcription. FlashCaps offer a route to regulate the expression of any
  given mRNA in vitro and in cells and may provide an approach to dose mRNA
  therapeutics with spatio-temporal control.
LAST-MODIFIED:20241206T101615Z
LOCATION:SYNMIKRO Lecture Hall
URL:https://www2.hrz.uni-marburg.de/en/synmikro/grk2937/whats-on/dates-and
 -events/speaker-series-andrea-rentmeister
END:VEVENT
BEGIN:VTIMEZONE
TZID:Europe/Berlin
X-LIC-LOCATION:Europe/Berlin
BEGIN:STANDARD
DTSTART:20241027T020000
TZNAME:CET
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
END:STANDARD
END:VTIMEZONE
END:VCALENDAR