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SUMMARY:Prof. Jue Wang\, University of Wisconsin-Madison and Mercator Fell
 ow of GRK 2937: Themes and Variations of Stress-Signaling Alarmones
DTSTART;TZID=Europe/Berlin:20250107T090000
DTEND;TZID=Europe/Berlin:20250107T100000
DTSTAMP:20260613T232521Z
UID:9198d1cad33e4876bdddec43aeb5318e@www2.hrz.uni-marburg.de
CREATED:20241205T124814Z
DESCRIPTION:https://www2.hrz.uni-marburg.de/en/synmikro/grk2937/whats-on/d
 ates-and-events/jue-wang-wisconsin-madison\nSpeaker Series. About the Wang
  Lab: Bacterial stress responses allow cells to survive fluctuating enviro
 nments\, antibiotic treatments\, and host defenses. My current research ai
 ms to answer the following fundamental questions: how do bacteria utilize 
 stress-induced small molecules to adapt to their specific environmental ni
 ches? How do bacteria enter a metabolically dormant persister state that i
 s intrinsically tolerant to a broad array of antibiotic treatments? How do
  stressed bacteria mitigate potential conflicts between their DNA replicat
 ion and transcription machineries to ensure survival? What are the molecul
 ar mechanisms of bacterial evolution to fit their specific niches? We comb
 ine metabolomics\, transcriptomics\, and proteomics with biochemical and e
 volutionary approaches to answer these questions. We study these processes
  in the Gram-positive bacterium Bacillus subtilis and the Gram-negative ba
 cterium Escherichia coli. These organisms grow fast and are highly amenabl
 e to genetic manipulation. Because the fundamentals of information process
 ing mechanisms are conserved across all domains of life\, our work in bact
 eria is broadly applicable to other\, less tractable\, systems.
LAST-MODIFIED:20241219T091513Z
LOCATION:SYNMIKRO Lecture Hall
URL:https://www2.hrz.uni-marburg.de/en/synmikro/grk2937/whats-on/dates-and
 -events/jue-wang-wisconsin-madison
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