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SUMMARY:Prof. Stephan Gruber\, University of Lausanne: SMC motors and swit
 ches in genome maintenance and DNA immunity
DTSTART;TZID=Europe/Berlin:20250520T090000
DTEND;TZID=Europe/Berlin:20250520T100000
DTSTAMP:20260614T042927Z
UID:9dfebfc5f2654bddbf477b20557f40ff@www2.hrz.uni-marburg.de
CREATED:20241205T125047Z
DESCRIPTION:https://www2.hrz.uni-marburg.de/en/synmikro/grk2937/whats-on/d
 ates-and-events/grk2937_speaker-series_stephan-gruber\nSpeaker Series.  Ab
 stract: SMC and SMC-like complexes are essential for chromosome organizati
 on and genome maintenance across the domains of life. Recently\, they have
  also emerged as key players in cellular immunity against foreign DNA. In 
 bacteria and archaea\, the Wadjet and Lamassu systems function in anti-pla
 smid and anti-phage defense\, while in humans\, the Smc5/6 and Rad50 compl
 exes contribute to antiviral immunity. This dual role presents an intrigui
 ng paradox: how can the same\, or closely related\, complexes preserve chr
 omosomal DNA while also recognizing and restricting extrachromosomal DNA? 
 I will discuss current insights into the role of these complexes in immuni
 ty\, including how core principles of SMC(-like) function may enable them 
 to differentiate and respond to linear or circular forms of invading DNA.
LAST-MODIFIED:20250512T084532Z
LOCATION:SYNMIKRO Lecture Hall
URL:https://www2.hrz.uni-marburg.de/en/synmikro/grk2937/whats-on/dates-and
 -events/grk2937_speaker-series_stephan-gruber
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DTSTART:20250330T030000
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