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SUMMARY:Prof. Fernando Moreno-Herrero\, Universidad Autónoma de Madrid\, 
 Spain: Single-molecule approaches to study protein machines involved in DN
 A metabolism
DTSTART;TZID=Europe/Berlin:20260119T160000
DTEND;TZID=Europe/Berlin:20260119T170000
DTSTAMP:20260614T013630Z
UID:9a505ca26c9b4e9fa722368378ae200f@www2.hrz.uni-marburg.de
CATEGORIES:()
CREATED:20241205T125047Z
DESCRIPTION:https://www2.hrz.uni-marburg.de/en/synmikro/grk2937/whats-on/d
 ates-and-events/grk2937_speaker-series_fernando-moreno-herrero\nSpeaker Se
 ries. Abstract: DNA metabolism is essential for the proper functioning of 
 the cell. It encompasses processes that preserve the stability\, structure
 \, and integrity of the genome\, including DNA repair mechanisms and highe
 r-order DNA organization. These tasks are performed by complex\, specializ
 ed protein machineries composed of low-copy number components that operate
  in a coordinated and often sequential manner. Many of these processes are
  inherently mechanical\, proceeding through a series of events that are ex
 quisitely regulated by force. Traditional biochemical methods provide ense
 mble-averaged measurements\, lack single-molecule resolution\, and offer l
 imited access to physical parameters such as force and directionality. As 
 a result\, they can obscure rare or atypical molecular behaviors that may 
 be crucial for proper cellular function.\nIn this talk\, I will introduce 
 two single-molecule techniques – Magnetic Tweezers and Optical Tweezers 
 – that enable us to study protein machines involved in DNA processing on
 e molecule at a time. Moreover\, by combining these approaches with fluore
 scence microscopy\, we can correlate the biological activity of molecular 
 motors with their spatial localization along the DNA. I will highlight sev
 eral ongoing projects\, including investigations of helicases and molecula
 r motors implicated in bacterial and eukaryotic double-strand break repair
 \, as well as studies of ParB and ParB-like proteins involved in bacterial
  chromosome segregation and gene regulation of multi-drug resistance plasm
 ids.
LAST-MODIFIED:20260109T083305Z
LOCATION:SYNMIKRO Lecture Hall
URL:https://www2.hrz.uni-marburg.de/en/synmikro/grk2937/whats-on/dates-and
 -events/grk2937_speaker-series_fernando-moreno-herrero
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TZID:Europe/Berlin
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DTSTART:20251026T020000
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TZOFFSETFROM:+0200
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