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SUMMARY:Prof. Fabian Commichau\, University of Hohenheim: Heat brings ligh
 t into the lysogeny-lysis decision system of the Bacillus subtilis SPβ pr
 ophage
DTSTART;TZID=Europe/Berlin:20250923T090000
DTEND;TZID=Europe/Berlin:20250923T100000
DTSTAMP:20260614T063038Z
UID:a18b7a7fe7a1499d92e81d564a63e890@www2.hrz.uni-marburg.de
CREATED:20241205T125047Z
DESCRIPTION:https://www2.hrz.uni-marburg.de/en/synmikro/grk2937/whats-on/d
 ates-and-events/grk2937_speaker-series_fabian-commichau\nSpeaker Series. A
 bstract: The temperate phage SPβinfects the endospore-forming Gram-positi
 ve bacterium Bacillus subtilis and resides as a prophage in its genome. Cu
 ltures of B. subtilis that are lysogenic for SPβ release the glycopeptide
  sublancin\, which inhibits the growth of SPβ-free B. subtilis strains by
  interfering with DNA replication and transcription. Thus\, SPβ is a host
 -benefitting trait after the transfer to another B. subtilis strain lackin
 g the prophage previously. Phages of the SPβgroup like phi3T use a peptid
 e-based communication system (termed the “arbitrium” system) to coordi
 nate lysis-lysogeny decisions. In the early stage of infection\, the numbe
 r of phages and the peptide concentration is low and a transcription antit
 erminator protein allows the synthesis of an antitoxin. Consequently\, lyt
 ic transcripts are not degraded and SPβ remains in the lytic cycle. With 
 increasing peptide concentrations\, the peptide enters the cell and inacti
 vates the transcription antiterminator protein. The lytic transcripts are 
 degraded\, and the phages enters the lysogenic state. Recently\, we have i
 dentified the master repressor of SPβ and a factor that acts downstream o
 f the repressor and is critical for the activation of the lytic cycle. Alt
 hough many additional components of the lysis-lysogeny decision system hav
 e already been identified\, it is unclear how the lysogenic cycle\, partic
 ularly in the case of the phage SPβ\, is activated. The current status of
  the project is presented.
LAST-MODIFIED:20250820T074403Z
LOCATION:SYNMIKRO Lecture Hall
URL:https://www2.hrz.uni-marburg.de/en/synmikro/grk2937/whats-on/dates-and
 -events/grk2937_speaker-series_fabian-commichau
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