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SUMMARY:Prof. Beatrix Süß\, TU Darmstadt: RNA aptamers as genetic contro
 l devices – the potential of synthetic riboswitches for regulating gene 
 expression
DTSTART;TZID=Europe/Berlin:20250603T090000
DTEND;TZID=Europe/Berlin:20250603T100000
DTSTAMP:20260613T215905Z
UID:c60eb50364c2432082d204647da43cb7@www2.hrz.uni-marburg.de
CREATED:20241205T125047Z
DESCRIPTION:https://www2.hrz.uni-marburg.de/en/synmikro/grk2937/whats-on/d
 ates-and-events/grk2937_speaker-series_beatrix-suess\nSpeaker Series. Abst
 ract: RNA utilises many different mechanisms to control gene expression. A
 mong the regulatory elements that respond to external stimuli\, riboswitch
 es are a prominent and elegant example. Riboswitches consist solely of RNA
 . They are characterised by binding of a small molecule ligand to the so-c
 alled aptamer domain\, which results in a conformational change of the dow
 nstream expression platform that determines the output of the system. The 
 modular organisation of riboswitches has resulted in the adoption of engin
 eered riboswitches as artificial genetic control devices and a number of e
 xciting proof-of-concept studies have been published. It should be noted t
 hat the majority of these studies were performed with the theophylline apt
 amer. Overall\, there is no shortage of small molecule-binding aptamers. H
 owever\, only a small fraction of them are suitable for RNA engineering si
 nce a classical SELEX protocol selects only for high-affinity binding but 
 not for conformational switching. We now implemented RNA Capture-SELEX in 
 our riboswitch developmental pipeline to integrate the required selection 
 for high-affinity binding with the equally necessary RNA conformational sw
 itching. We consider this integrated approach a breakthrough in riboswitch
  development\, as suitable sensor domains for RNA-based devices can now be
  developed quickly and easily against any ligand of choice.
LAST-MODIFIED:20250527T075938Z
LOCATION:SYNMIKRO Lecture Hall
URL:https://www2.hrz.uni-marburg.de/en/synmikro/grk2937/whats-on/dates-and
 -events/grk2937_speaker-series_beatrix-suess
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